SERVICE 02

Systematic Literature Search
& Evidence Synthesis

The translation of findings from biomedical research into widespread patient care requires irrefutable scientific justification. Zelsya acts as an independent, scientific think tank in this regard: We are commissioned by health insurance associations and healthcare institutions to conduct completely neutral evaluations of new, innovative diagnostic procedures – such as state-of-the-art biomarkers, liquid biopsies, or complex gene sequencing – before their potential introduction into the healthcare system.

As a specialized boutique agency, we conduct methodologically rigorous evidence syntheses. Neutral, transparent and compliant, we analyze the global peer-reviewed literature and produce precise scientific reports and reviews that provide a reliable answer to the core question: Does the introduction of this diagnostic procedure into the healthcare system make sense based on the current state of translational research?

Identifying gaps in scientific evidence

We analyze the published research to identify what is available and what is missing. For health insurance associations, we uncover the scientific gaps at the interface between laboratory research and clinical application.

Assessment of translational maturity and biological plausibility: We critically examine whether a diagnostic procedure has successfully made the leap from theoretical basic research to translational practice. Thanks to our deep roots in molecular biology, we examine the functional relevance of genes and markers and assess whether the available peer-reviewed data scientifically justify widespread implementation in the healthcare system.

Identifying deficiencies in published studies: We identify methodological gaps in the study design of published articles. These include insufficient sample sizes, a lack of representative control groups, or inadequate long-term data, which make a reliable assessment of the method difficult.

Validation of the actual medical benefit : We investigate whether there is an evidence gap in the literature regarding the concrete patient benefit. Does the peer-reviewed research show that the procedure measurably improves therapeutic decisions in real-world clinical practice, or does it merely provide translational laboratory parameters without genuine clinical added value?

Identifying biases and contradictions : We analyze the entire body of published literature to uncover systematic biases or unresolved contradictions in the study results. This allows us to precisely identify areas where significant further research is needed for the associations.

Our services at a glance

Systematic Literature Search & Scoping Literature Review Articles

Methodologically sound preparation of the global, peer-reviewed body of research on medical, translational, molecular biological and diagnostic issues.

Evidence syntheses & Literature Search Reports

Structured syntheses of clinical and translational data as an objective, value-free decision-making aid for associations and committees.

Evidence Gap Analyses

Systematic review and documentation of gaps or insufficient evidence in published research literature.

Your advantage: Independent Analysis & High-Level Expertise

A completely neutral data analysis: Our reports are entirely independent and based exclusively on valid, peer-reviewed data. We provide you with an unbiased analysis of the current state of research – free from any health policy interests.

Deep expertise in genomics and molecular biology: We understand the biological mechanisms and gene functions behind modern high-performance diagnostics. This allows us to rigorously examine the scientific data and determine the data quality.

Relief for review boards: We take over the extremely time-consuming, methodical screening and critical analysis of the literature, so that your experts can directly access a finished, rigorous scientific document.